Genomic analysis of enterovirus D68, including one strain isolated from a child with Wilson's disease in Taiwan

Yeh-Sheng Chien; Shu-Ting Luo; Kuo-Chien Tsao; Ying-Hsiang Wang; Tzou-Yien Lin; Yhu-Chering Huang; Min-Shi Lee

Journal of the Formosan Medical Association (Feb 2019)

Genomic analysis of enterovirus D68, including one strain isolated from a child with Wilson's disease in Taiwan

Yeh-Sheng Chien,
Shu-Ting Luo,
Kuo-Chien Tsao,
Ying-Hsiang Wang,
Tzou-Yien Lin,
Yhu-Chering Huang,
Min-Shi Lee

Affiliations

Yeh-Sheng Chien: National Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Department of Life Sciences, National Central University, Taoyuan, Taiwan
Shu-Ting Luo: National Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan, Miaoli County, Taiwan
Kuo-Chien Tsao: Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Guishan, Taoyuan County, Taiwan; Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Guishan, Taoyuan County, Taiwan
Ying-Hsiang Wang: Department of Pediatrics, Chiayi Chang Gung Memorial Hospital, Puzi, Chiayi County, Taiwan
Tzou-Yien Lin: Department of Pediatrics, Linkou Chang Gung Memorial Hospital, Guishan, Taoyuan County, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Guishan, Taoyuan County, Taiwan
Yhu-Chering Huang: Department of Pediatrics, Chiayi Chang Gung Memorial Hospital, Puzi, Chiayi County, Taiwan
Min-Shi Lee: National Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Corresponding author. R1-7F, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan. Fax: +886 37 586 457.

Journal volume & issue: Vol. 118, no. 2
pp. 641 – 646

Abstract

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North America experienced life-threatening outbreaks of enterovirus D68 (EV-D68) in 2014. We retrospectively detected EV-D68 from a child with Wilson's disease in 2008 in Taiwan. After comparing this EV-D68/Taiwan/2008 strain with EV-D68 genomes obtained from the public domain, it was classified as genome type 1-B; it is phylogenetically related to the predominant EV-D68 viruses that circulated in 2009 in Vietnam. It is necessary to strengthen EV-D68 detection globally, including in children with acute liver failure. Moreover, harmonization of genomic analysis of EV-D68 is desirable to understand global evolution of EV-D68. Keywords: Enterovirus D68, Genome study, Molecular epidemiology, Next-generation sequencing

Published in Journal of the Formosan Medical Association

ISSN: 0929-6646 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General)
Website: http://www.journals.elsevier.com/journal-of-the-formosan-medical-association/

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