Nature Communications (Sep 2020)
The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16
- Dawei Shi,
- Xian Xia,
- Aoyuan Cui,
- Zhongxiang Xiong,
- Yizhen Yan,
- Jing Luo,
- Guoyu Chen,
- Yingying Zeng,
- Donghong Cai,
- Lei Hou,
- Joseph McDermott,
- Yu Li,
- Hong Zhang,
- Jing-Dong J. Han
Affiliations
- Dawei Shi
- Key Laboratory of Computational Biology, Chinese Academy of Sciences–Max Planck Partner Institute for Computational Biology (PICB), Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Collaborative Innovation Center for Genetics and Developmental Biology, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS)
- Xian Xia
- Key Laboratory of Computational Biology, Chinese Academy of Sciences–Max Planck Partner Institute for Computational Biology (PICB), Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Collaborative Innovation Center for Genetics and Developmental Biology, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS)
- Aoyuan Cui
- University of Chinese Academy of Sciences
- Zhongxiang Xiong
- Key Laboratory of Computational Biology, Chinese Academy of Sciences–Max Planck Partner Institute for Computational Biology (PICB), Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Collaborative Innovation Center for Genetics and Developmental Biology, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS)
- Yizhen Yan
- Key Laboratory of Computational Biology, Chinese Academy of Sciences–Max Planck Partner Institute for Computational Biology (PICB), Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Collaborative Innovation Center for Genetics and Developmental Biology, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS)
- Jing Luo
- Key Laboratory of Computational Biology, Chinese Academy of Sciences–Max Planck Partner Institute for Computational Biology (PICB), Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Collaborative Innovation Center for Genetics and Developmental Biology, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS)
- Guoyu Chen
- Key Laboratory of Computational Biology, Chinese Academy of Sciences–Max Planck Partner Institute for Computational Biology (PICB), Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Collaborative Innovation Center for Genetics and Developmental Biology, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS)
- Yingying Zeng
- Key Laboratory of Computational Biology, Chinese Academy of Sciences–Max Planck Partner Institute for Computational Biology (PICB), Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Collaborative Innovation Center for Genetics and Developmental Biology, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS)
- Donghong Cai
- Key Laboratory of Computational Biology, Chinese Academy of Sciences–Max Planck Partner Institute for Computational Biology (PICB), Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Collaborative Innovation Center for Genetics and Developmental Biology, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS)
- Lei Hou
- Key Laboratory of Computational Biology, Chinese Academy of Sciences–Max Planck Partner Institute for Computational Biology (PICB), Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Collaborative Innovation Center for Genetics and Developmental Biology, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS)
- Joseph McDermott
- Key Laboratory of Computational Biology, Chinese Academy of Sciences–Max Planck Partner Institute for Computational Biology (PICB), Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Collaborative Innovation Center for Genetics and Developmental Biology, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS)
- Yu Li
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, SINH, SIBS, CAS
- Hong Zhang
- University of Chinese Academy of Sciences
- Jing-Dong J. Han
- Key Laboratory of Computational Biology, Chinese Academy of Sciences–Max Planck Partner Institute for Computational Biology (PICB), Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Collaborative Innovation Center for Genetics and Developmental Biology, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS)
- DOI
- https://doi.org/10.1038/s41467-020-18280-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Phosphatidylinositol 3-kinase catalyzes the reaction from PI(4,5)P2 to PI(3,4,5)P3 and is encoded by the age-1 gene known to regulate lifespan. Here the researchers found that the metabolite myo-inositol, which can be converted to PI(3,4,5)P3 extends worm lifespan and alleviates worm as well as mouse health decline during aging.
