Nature Communications (Oct 2022)
Vitamin C epigenetically controls osteogenesis and bone mineralization
- Roman Thaler,
- Farzaneh Khani,
- Ines Sturmlechner,
- Sharareh S. Dehghani,
- Janet M. Denbeigh,
- Xianhu Zhou,
- Oksana Pichurin,
- Amel Dudakovic,
- Sofia S. Jerez,
- Jian Zhong,
- Jeong-Heon Lee,
- Ramesh Natarajan,
- Ivo Kalajzic,
- Yong-hui Jiang,
- David R. Deyle,
- Eleftherios P. Paschalis,
- Barbara M. Misof,
- Tamas Ordog,
- Andre J. van Wijnen
Affiliations
- Roman Thaler
- Department of Orthopedic Surgery, Mayo Clinic
- Farzaneh Khani
- Department of Orthopedic Surgery, Mayo Clinic
- Ines Sturmlechner
- Departments of Pediatric and Adolescent Medicine, Mayo Clinic
- Sharareh S. Dehghani
- Department of Orthopedic Surgery, Mayo Clinic
- Janet M. Denbeigh
- Department of Orthopedic Surgery, Mayo Clinic
- Xianhu Zhou
- Department of Orthopedic Surgery, Mayo Clinic
- Oksana Pichurin
- Department of Orthopedic Surgery, Mayo Clinic
- Amel Dudakovic
- Department of Orthopedic Surgery, Mayo Clinic
- Sofia S. Jerez
- Department of Orthopedic Surgery, Mayo Clinic
- Jian Zhong
- Epigenomics Program, Center for Individualized Medicine, Mayo Clinic
- Jeong-Heon Lee
- Department of Biochemistry & Molecular Biology, Mayo Clinic
- Ramesh Natarajan
- Department of Internal Medicine, Virginia Commonwealth University
- Ivo Kalajzic
- Department of Reconstructive Sciences, UConn Health
- Yong-hui Jiang
- Department of Genetics, Neuroscience, and Pediatrics, Yale University School of Medicine
- David R. Deyle
- Department of Clinical Genomics, Mayo Clinic
- Eleftherios P. Paschalis
- Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1st Med. Dept. Hanusch Hospital
- Barbara M. Misof
- Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1st Med. Dept. Hanusch Hospital
- Tamas Ordog
- Epigenomics Program, Center for Individualized Medicine, Mayo Clinic
- Andre J. van Wijnen
- Department of Biochemistry, University of Vermont
- DOI
- https://doi.org/10.1038/s41467-022-32915-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
For decades vitamin C’s primary function in bone has been attributed to its involvement in collagen synthesis. Here, the authors uncover that vitamin C’s central role in bone is to globally orchestrate osteogenesis via epigenetic mechanisms.
