Dutch population structure across space, time and GWAS design

Ross P. Byrne; Wouter van Rheenen; Project MinE ALS GWAS Consortium; Leonard H. van den Berg; Jan H. Veldink; Russell L. McLaughlin

doi:10.1038/s41467-020-18418-4

Nature Communications (Sep 2020)

Dutch population structure across space, time and GWAS design

Ross P. Byrne,
Wouter van Rheenen,
Project MinE ALS GWAS Consortium,
Leonard H. van den Berg,
Jan H. Veldink,
Russell L. McLaughlin

Affiliations

Ross P. Byrne: Smurfit Institute of Genetics, Trinity College Dublin
Wouter van Rheenen: Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht
Project MinE ALS GWAS Consortium
Leonard H. van den Berg: Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht
Jan H. Veldink: Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht
Russell L. McLaughlin: Smurfit Institute of Genetics, Trinity College Dublin

DOI: https://doi.org/10.1038/s41467-020-18418-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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Genetic variation in modern humans can reveal information about a population’s history and migration patterns. Here, the authors describe the ancestry and geospatial genetic structure of the Netherlands, and demonstrate the utility of haplotype-based covariates in genome-wide association studies.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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