Is it worthwhile rethinking the positive experience of the last 50 years of using chondroitin sulfates against atherosclerosis?

Abstract

Chondroitin sulfate (CS) and glucosamine sulfate (GS) are used in the treatment of osteoarthritis and exhibit a pronounced anti-inflammatory effect. CS/GS inhibit the NF-kB signaling cascade, which realizes the biological effects of tumor necrosis factor (TNFa). Excessive activity of NF-kB also stimulates the development of atherosclerosis. The results of experimental and clinical studies show that inhibition of NF-kB by CS/GS will inhibit the formation and growth of atherosclerotic plaques also reducing levels of other markers of inflammation.

Keywords

• chondroitin sulfate
• glucosamine sulfate
• atherosclerosis
• inflammation
• chondroguard
• sustaguard artro