Nature Communications (Oct 2018)
Multi-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitors
- Luca Urbani,
- Carlotta Camilli,
- Demetra-Ellie Phylactopoulos,
- Claire Crowley,
- Dipa Natarajan,
- Federico Scottoni,
- Panayiotis Maghsoudlou,
- Conor J. McCann,
- Alessandro Filippo Pellegata,
- Anna Urciuolo,
- Koichi Deguchi,
- Sahira Khalaf,
- Salvatore Ferdinando Aruta,
- Maria Cristina Signorelli,
- David Kiely,
- Edward Hannon,
- Matteo Trevisan,
- Rui Rachel Wong,
- Marc Olivier Baradez,
- Dale Moulding,
- Alex Virasami,
- Asllan Gjinovci,
- Stavros Loukogeorgakis,
- Sara Mantero,
- Nikhil Thapar,
- Neil Sebire,
- Simon Eaton,
- Mark Lowdell,
- Giulio Cossu,
- Paola Bonfanti,
- Paolo De Coppi
Affiliations
- Luca Urbani
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Carlotta Camilli
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Demetra-Ellie Phylactopoulos
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Claire Crowley
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Dipa Natarajan
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Federico Scottoni
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Panayiotis Maghsoudlou
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Conor J. McCann
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Alessandro Filippo Pellegata
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Anna Urciuolo
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Koichi Deguchi
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Sahira Khalaf
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Salvatore Ferdinando Aruta
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Maria Cristina Signorelli
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- David Kiely
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Edward Hannon
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Matteo Trevisan
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Rui Rachel Wong
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Marc Olivier Baradez
- Cell and Gene Therapy Catapult
- Dale Moulding
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Alex Virasami
- Department of Histopathology, Great Ormond Street Hospital, University College of London
- Asllan Gjinovci
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Stavros Loukogeorgakis
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Sara Mantero
- Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”
- Nikhil Thapar
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Neil Sebire
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Simon Eaton
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Mark Lowdell
- Royal Free London NHS FT & UCL
- Giulio Cossu
- Division of Cell Matrix and Regenerative Medicine, Manchester Academic Health Centre, University of Manchester
- Paola Bonfanti
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- Paolo De Coppi
- Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London
- DOI
- https://doi.org/10.1038/s41467-018-06385-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Combining decellularised scaffolds with patient-derived cells holds promise for bioengineering of functional tissues. Here the authors develop a two-stage approach to engineer an oesophageal graft that retains the structural organisation of native oesophagus.
