mBio (Feb 2021)

Salmonella enterica Serovar Typhimurium Exploits Cycling through Epithelial Cells To Colonize Human and Murine Enteroids

  • Petra Geiser,
  • Maria Letizia Di Martino,
  • Pilar Samperio Ventayol,
  • Jens Eriksson,
  • Eduardo Sima,
  • Anas Kh. Al-Saffar,
  • David Ahl,
  • Mia Phillipson,
  • Dominic-Luc Webb,
  • Magnus Sundbom,
  • Per M. Hellström,
  • Mikael E. Sellin

DOI
https://doi.org/10.1128/mBio.02684-20
Journal volume & issue
Vol. 12, no. 1

Abstract

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Pathogenic gut bacteria are common causes of intestinal disease. Enteroids—cultured three-dimensional replicas of the mammalian gut—offer an emerging model system to study disease mechanisms under conditions that recapitulate key features of the intestinal tract.