THE STATE OF GLUTATHIONE SYSTEM IN RAT TISSUES WITH TRAUMA MUSCULOSKELETAL SYSTEM IN THE METHIONINE INDUCED HYPERHOMOCYSTEINEMIA

Abstract

Purpose: to research the glutathione system state in rat tissues after trauma of the musculoskeletal system in a methionineinduced hyperhomocysteinemia.Materials and methods: the level of homocysteine in the plasma of animals, as well as the amount of glutathione and glutathione peroxidase enzyme activity, glutathione-S-transferase, glutathione reductase in the erythrocyte hemolysate, liver homogenates and cardiac muscle have been determined.Results: it has been found that in the animals with experimental hyperhomocysteinemia and musculoskeletal injury the liver and erythrocyte glutathione system components react.Conclusions: an increase of glutathione content and activity change of glutathione peroxidase, glutathione-S-transferase and glutathione reductase in different tissues have been shown.

Keywords

• hyperhomocysteinemia, thrombophilia, trauma, glutathione system, oxidative stress