Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases

Huiyun Peng; Keishi Ishida; Yuki Sugimoto; Holger Jenke-Kodama; Christian Hertweck

doi:10.1038/s41467-019-11896-1

Nature Communications (Sep 2019)

Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases

Huiyun Peng,
Keishi Ishida,
Yuki Sugimoto,
Holger Jenke-Kodama,
Christian Hertweck

Affiliations

Huiyun Peng: Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Beutenbergstrasse 11a
Keishi Ishida: Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Beutenbergstrasse 11a
Yuki Sugimoto: Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Beutenbergstrasse 11a
Holger Jenke-Kodama: Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku
Christian Hertweck: Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Beutenbergstrasse 11a

DOI: https://doi.org/10.1038/s41467-019-11896-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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The wealth of complex polyketides is an essential source for drug discovery. Here, the authors report an evolution-guided rational morphing of modular polyketide synthases (PKSs) for aurothin and neoaurothin biosynthesis, and reveal engineering site suitable for diversifying PKS systems.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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