Scripta Medica (Jan 2018)
Open surgical biopsy in diagnosis of mammographically detected suspicious microcalcifcations
Abstract
Background: One of the earliest signs of breast cancer may be the presence of mammographically detected suspicious microcalcifcations in the breast. The aim of the study was to present an open surgical biopsy of the mammographically detected suspicious microcalcifcations in a breast, with preoperative wire marking of the lesions and intraoperative specimen radiography, as a reliable and valid procedure. Material and Methods: The study included 80 female patients underwent surgery because of mammographically detected suspicious microcalcifcations. The method of preoperative ultrasound-guided wire marking of a zone of microcalcifcation was performed in all patients. After wire marking, the control native mammography in ML and CC projections was performed, in order to locate the microcalcifcations relative to the wire. In all patients, the extirpation of the suspicious microcalcifcations was verified by the specimen radiography. Results: In the definitive histopathological finding in situ component of ductal carcinoma of the breast was verified in nine (11,25%) examinees. High grade in situ component was verified in eight (10%) examinees and low grade in situ component in one examinee (1,25%). In 11 (13,75%) examinees, the invasive breast cancer with an extensive in situ component up to 50% was verified. In 46 (57,5%) of the examinees, benign, non-proliferative changes were verified, while proliferative changes characterized as premalignant condition (sclerosing adenosis, radial scar and atypical ductal hyperplasia) were verified in 14 (17,5%) examinees. Microcalcifcations verified by specimen radiography are completely removed. Conclusion: Presence of mammographically detected suspicious microcalcifcations has a significant predictive value in the early detection of breast cancer. The method of an open surgical biopsy, as an alternative to stereotactic biopsy, is valid in diagnostic of the mammographically suspicious microcalcifcations.
