Recent Applications on Dual-Catalysis for C–C and C–X Cross-Coupling Reactions

Abstract

Coupling reactions stand amid the most significant reactions in synthetic organic chemistry. Of late, these coupling strategies are being viewed as a versatile synthetic tool for a wide range of organic transformations in many sectors of chemistry, ranging from indispensable synthetic scaffolds and natural products of biological significance to novel organic materials. Further, the use of dual-catalysis in accomplishing various interesting cross-coupling transformations is an emerging field in synthetic organic chemistry, owing to their high catalytic performance rather than the use of a single catalyst. In recent years, synthetic organic chemists have given considerable attention to hetero-dual catalysis; wherein these catalytic systems have been employed for the construction of versatile carbon–carbon [C(sp 3)–C(sp 3), C(sp 3)–C(sp 2), C(sp 2)–C(sp 2)] and carbon–heteroatom (C–N, C–O, C–P, C–S) bonds. Therefore, in this mini-review, we are emphasizing recently developed various cross-coupling reactions catalysed by transition-metal dual-catalysis (i.e., using palladium and copper catalysts, but omitting the reports on photoredox/metal catalysis). 1 Introduction 2 Cu/Pd-Catalysed Bond Formation 2.1 Pd/Cu-Catalysed C(sp 3)–C(sp 2) Bond Formation 2.2 Pd/Cu-Catalysed C(sp 2)–C(sp 2) Bond Formation 2.3 Pd/Cu-Catalysed C(sp)–C(sp 2) Bond Formation 2.4 Pd/Cu-Catalysed C(sp 3)–C(sp 3) Bond Formation 2.5 Pd/Cu-Catalysed C–X (X = B, N, P, S, Si) Bond Formation 3 Conclusion

Keywords

• dual-metal catalysis
• cross-coupling reactions
• kinugasa reaction
• palladium catalysis
• heterocycles