Frontiers in Immunology (Mar 2024)

The role of TIM-3 in sepsis: a promising target for immunotherapy?

  • Changli Wang,
  • Jinhai Liu,
  • Qi Wu,
  • Zhi Wang,
  • Baoji Hu,
  • Lulong Bo

DOI
https://doi.org/10.3389/fimmu.2024.1328667
Journal volume & issue
Vol. 15

Abstract

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Sepsis remains a significant cause of mortality and morbidity worldwide, with limited effective treatment options. The T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) has emerged as a potential therapeutic target in various immune-related disorders. This narrative review aims to explore the role of TIM-3 in sepsis and evaluate its potential as a promising target for immunotherapy. We discuss the dynamic expression patterns of TIM-3 during sepsis and its involvement in regulating immune responses. Furthermore, we examine the preclinical studies investigating the regulation of TIM-3 signaling pathways in septic models, highlighting the potential therapeutic benefits and challenges associated with targeting TIM-3. Overall, this review emphasizes the importance of TIM-3 in sepsis pathogenesis and underscores the promising prospects of TIM-3-based immunotherapy as a potential strategy to combat this life-threatening condition.

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