Voltage-gated proton channels from fungi highlight role of peripheral regions in channel activation

Abstract

Chang Zhao and Francesco Tombola identify and characterize distinct biophysical properties among voltage-gated proton channels in Basidiomycota and Ascomycota fungi. By generating chimeric channel proteins, the authors also report that intra- and extracellular peripheral regions are key determinants of channel properties, providing important insight on fungal physiology.