Neural Regeneration Research (Jan 2015)
MicroRNA-124 slows down the progression of Huntington′s disease by promoting neurogenesis in the striatum
- Tian Liu,
- Wooseok Im,
- Inhee Mook-Jung,
- Manho Kim
Affiliations
- Tian Liu
- Wooseok Im
- Inhee Mook-Jung
- Manho Kim
- DOI
- https://doi.org/10.4103/1673-5374.156978
- Journal volume & issue
-
Vol. 10,
no. 5
pp. 786 – 791
Abstract
MicroRNA-124 contributes to neurogenesis through regulating its targets, but its expression both in the brain of Huntington′s disease mouse models and patients is decreased. However, the effects of microRNA-124 on the progression of Huntington′s disease have not been reported. Results from this study showed that microRNA-124 increased the latency to fall for each R6/2 Huntington′s disease transgenic mouse in the rotarod test. 5-Bromo-2′-deoxyuridine (BrdU) staining of the striatum shows an increase in neurogenesis. In addition, brain-derived neurotrophic factor and peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein levels in the striatum were increased and SRY-related HMG box transcription factor 9 protein level was decreased. These findings suggest that microRNA-124 slows down the progression of Huntington′s disease possibly through its important role in neuronal differentiation and survival.
Keywords
- active zone stability
- Drosophila
- neuromuscular junction
- dephosphorylation
- Liprin-α
- Syd-1
- PP2A
- GSK-3ß
- living scaffolds
- neural tissue engineering
- cell transplant
- biomaterials
- regeneration
- neurotrauma
- neurodegeneration
- axon pathfinding
- cell migration
- injury
- plasticity
- neurodegenerative disease
- brain
- therapy
- neuron
- microglia
- neural progenitor
- tissue engineering
- neuroregeneration
- repair
- central nervous system
- biomaterial
- regenerative medicine
- nanotechnology
- spinal cord injury
- axonal regeneration
- exosome
- extracellular vesicle
- microRNA
- microvesicle
- nerve gap
- neurite outgrowth
- peripheral nerve injury
- Schwann cell
- stem cell
- hemodynamic phases
- cerebral subarachnoid hemorrhage
- metabolic crises
- nerve regeneration
- hypoxic-ischemic brain damage
- ginsenoside Rg1
- neural stem cells
- cell transplantation
- cell differentiation
- cognition
- nerve reconstruction
- neural regeneration
- nerve regeneration
- brain injury
- neuroimaging
- functional magnetic resonance imaging
- regional homogeneity
- apoplexy
- subacute
- ischemia
- participants
- healthy
- volunteers
- brain activity
- NSFC grants
- neural regeneration
- nerve regeneration
- brain injury
- neuroprotection
- cerebral ischemia/reperfusion injury
- lateral intracerebroventricular injection
- Apelin-13
- nerve apoptosis
- Bcl-2
- caspase-3
- NSFC grants
- neural regeneration
- nerve regeneration
- fractalkine
- CX3 chemokine receptor 1
- neuronal maturation
- dendrites
- doublecortin
- synaptic maturation
- newborn neurons
- neural regeneration
- nerve regeneration
- neurodegenerative diseases
- Alzheimer′s disease
- transgenic animal models
- mice
- epimedium herb
- milkvetch root
- kudzuvine root
- divalent metal transporter 1
- ferroportin 1
- neural regeneration
- nerve regeneration
- microRNA-124
- neurogenesis
- neuronal survival
- Huntington′s disease
- SRY-related HMG box transcription factor 9
- brain-derived neurotrophic factor
- peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- mutant huntingtin
