Communications Biology (Mar 2023)
YgfB increases β-lactam resistance in Pseudomonas aeruginosa by counteracting AlpA-mediated ampDh3 expression
- Ole Eggers,
- Fabian A. Renschler,
- Lydia Anita Michalek,
- Noelle Wackler,
- Elias Walter,
- Fabian Smollich,
- Kristina Klein,
- Michael S. Sonnabend,
- Valentin Egle,
- Angel Angelov,
- Christina Engesser,
- Marina Borisova,
- Christoph Mayer,
- Monika Schütz,
- Erwin Bohn
Affiliations
- Ole Eggers
- Institute for Medical Microbiology and Hygiene, Interfaculty Institute of Microbiology and Infection Medicine (IMIT), Eberhard Karls University Tübingen
- Fabian A. Renschler
- Institute for Medical Microbiology and Hygiene, Interfaculty Institute of Microbiology and Infection Medicine (IMIT), Eberhard Karls University Tübingen
- Lydia Anita Michalek
- Institute for Medical Microbiology and Hygiene, Interfaculty Institute of Microbiology and Infection Medicine (IMIT), Eberhard Karls University Tübingen
- Noelle Wackler
- Institute for Medical Microbiology and Hygiene, Interfaculty Institute of Microbiology and Infection Medicine (IMIT), Eberhard Karls University Tübingen
- Elias Walter
- Institute for Medical Microbiology and Hygiene, Interfaculty Institute of Microbiology and Infection Medicine (IMIT), Eberhard Karls University Tübingen
- Fabian Smollich
- Institute for Medical Microbiology and Hygiene, Interfaculty Institute of Microbiology and Infection Medicine (IMIT), Eberhard Karls University Tübingen
- Kristina Klein
- Institute for Medical Microbiology and Hygiene, Interfaculty Institute of Microbiology and Infection Medicine (IMIT), Eberhard Karls University Tübingen
- Michael S. Sonnabend
- Institute for Medical Microbiology and Hygiene, Interfaculty Institute of Microbiology and Infection Medicine (IMIT), Eberhard Karls University Tübingen
- Valentin Egle
- Institute for Medical Microbiology and Hygiene, Interfaculty Institute of Microbiology and Infection Medicine (IMIT), Eberhard Karls University Tübingen
- Angel Angelov
- NGS Competence Center Tübingen (NCCT), Institute for Medical Microbiology and Hygiene, Eberhard Karls University Tübingen
- Christina Engesser
- NGS Competence Center Tübingen (NCCT), Institute for Medical Microbiology and Hygiene, Eberhard Karls University Tübingen
- Marina Borisova
- Cluster of Excellence “Controlling Microbes to Fight Infections”, University of Tübingen
- Christoph Mayer
- Cluster of Excellence “Controlling Microbes to Fight Infections”, University of Tübingen
- Monika Schütz
- Institute for Medical Microbiology and Hygiene, Interfaculty Institute of Microbiology and Infection Medicine (IMIT), Eberhard Karls University Tübingen
- Erwin Bohn
- Institute for Medical Microbiology and Hygiene, Interfaculty Institute of Microbiology and Infection Medicine (IMIT), Eberhard Karls University Tübingen
- DOI
- https://doi.org/10.1038/s42003-023-04609-4
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 17
Abstract
YgfB regulates β-lactam resistance in Pseudomonas aeruginosa in part by interacting with the programmed cell death pathway regulator, AlpA, and repressing expression of the amidase, AmpDh3.
