Nature Communications (Mar 2021)
Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection
- Zhongfang Wang,
- Xiaoyun Yang,
- Jiaying Zhong,
- Yumin Zhou,
- Zhiqiang Tang,
- Haibo Zhou,
- Jun He,
- Xinyue Mei,
- Yonghong Tang,
- Bijia Lin,
- Zhenjun Chen,
- James McCluskey,
- Ji Yang,
- Alexandra J. Corbett,
- Pixin Ran
Affiliations
- Zhongfang Wang
- State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University
- Xiaoyun Yang
- State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University
- Jiaying Zhong
- State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University
- Yumin Zhou
- State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University
- Zhiqiang Tang
- The Second Peoples Hospital of Changde City
- Haibo Zhou
- The Sixth Affiliated Hospital of Guangzhou Medical University
- Jun He
- Affiliated Nanhua Hospital of University of South China
- Xinyue Mei
- State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University
- Yonghong Tang
- Affiliated Nanhua Hospital of University of South China
- Bijia Lin
- State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University
- Zhenjun Chen
- The Department of Microbiology and Immunology and The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne
- James McCluskey
- The Department of Microbiology and Immunology and The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne
- Ji Yang
- State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University
- Alexandra J. Corbett
- The Department of Microbiology and Immunology and The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne
- Pixin Ran
- State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University
- DOI
- https://doi.org/10.1038/s41467-021-22036-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 8
Abstract
T cells compose a critical component of the immune response to coronavirus infection with SARS-CoV-2. Here the authors characterise the T cell response to SARS CoV-2 in patients and their close contacts, and show the presence of SARS-CoV-2 specific T cells in the absence of detectable virus infection.
