Current approaches to development of contrast agents for MRI diagnostics

Abstract

Magnetic resonance imaging (MRI) is primarily used in medical imaging to visualize the structure and function of the body and essential tool for diagnostics of broad range of pathologies. But still in a growing number of cases there are indications to use contrast agent to delineate areas of interest and for more precise diagnosis definition. In a review the properties and clinical applications of most popular paramagnetic contrast agents based on Gd(III), Fe(II) и Mn(II) are discussed. It is also focused on discussion of modern experimental targeted contrast agents (conjugates of antibodies, nanoparticles and dendrimers) and advances of their application for early diagnostics of most common pathologies: cardiovascular, cancer and Alzheimer diseases.

Keywords

• магнитно-резонансная томография
• контрастные агенты для мрт
• экспериментальные контрастные препараты