Nature Communications (Oct 2019)
Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele
- Hussein Al-Mossawi,
- Nicole Yager,
- Chelsea A. Taylor,
- Evelyn Lau,
- Sara Danielli,
- Jelle de Wit,
- James Gilchrist,
- Isar Nassiri,
- Elise A. Mahe,
- Wanseon Lee,
- Laila Rizvi,
- Seiko Makino,
- Jane Cheeseman,
- Matt Neville,
- Julian C. Knight,
- Paul Bowness,
- Benjamin P. Fairfax
Affiliations
- Hussein Al-Mossawi
- Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford
- Nicole Yager
- Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford
- Chelsea A. Taylor
- Department of Oncology, Weatherall Institute of Molecular Medicine
- Evelyn Lau
- Wellcome Centre for Human Genetics, University of Oxford
- Sara Danielli
- Department of Oncology, Weatherall Institute of Molecular Medicine
- Jelle de Wit
- Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford
- James Gilchrist
- Wellcome Centre for Human Genetics, University of Oxford
- Isar Nassiri
- Department of Oncology, Weatherall Institute of Molecular Medicine
- Elise A. Mahe
- Department of Oncology, Weatherall Institute of Molecular Medicine
- Wanseon Lee
- Wellcome Centre for Human Genetics, University of Oxford
- Laila Rizvi
- Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford
- Seiko Makino
- Wellcome Centre for Human Genetics, University of Oxford
- Jane Cheeseman
- Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
- Matt Neville
- Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
- Julian C. Knight
- Wellcome Centre for Human Genetics, University of Oxford
- Paul Bowness
- Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford
- Benjamin P. Fairfax
- Department of Oncology, Weatherall Institute of Molecular Medicine
- DOI
- https://doi.org/10.1038/s41467-019-12393-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Interleukin-7 (IL-7) is a central cytokine in T cell homeostasis. Here the authors show that allelic variation at rs6897932, an autoimmune GWAS risk allele at IL7R, regulates surface and soluble IL-7R in stimulated monocytes, indicating a function of monocytes in IL-7-related autoimmunity.
