A NEW ANTIEPILEPTIC DRUG — ZONEGRAN (ZONISAMIDE) — IN THE TREATMENT OF EPILEPSY (A REVIEW)

Abstract

Despite the considerable advances of epileptology drug-resistant epilepsies consist about 30% among all forms of epilepsy. Authors represent the review of the literature devoted to efficacy and tolerability of zonisamide in the treatment of drug-resistant epilepsy. The current review of studies devoted to efficacy and safety of a new antiepileptic drug zonisamide in the treatment of epilepsy is proposed. The mechanism of action and pharmacokinetic of zonisamide are described; the questions of efficacy and tolerability in the treatment of drug-resistant focal epilepsies and other types of seizures and forms of epilepsy are considered. The possibilities of the use of the drug in the treatment of comorbid disorders are considered

Keywords

• epilepsy
• drug-resistant epilepsy
• zonisamide
• efficacy
• tolerability.