Acta Pharmaceutica Sinica B (Dec 2024)
Comparison of Jinzhen oral liquid and ambroxol hydrochloride and clenbuterol hydrochloride oral solution in the treatment of acute bronchitis in children: A multicenter, non-inferiority, prospective, randomized controlled trial
- Qinhua Fan,
- Chongming Wu,
- Yawei Du,
- Boyang Wang,
- Yanming Xie,
- Zeling Zhang,
- Wenquan Su,
- Zizhuo Wang,
- Changchang Xu,
- Xueke Li,
- Ying Ding,
- Xinjiang An,
- Jing Chen,
- Yunying Xiao,
- Rong Yu,
- Nan Li,
- Juan Wang,
- Yiqun Teng,
- Hongfen Lv,
- Nian Yang,
- Yuling Wen,
- Xiaoli Huang,
- Wei Pan,
- Yufeng Liu,
- Xueqin Xi,
- Qianye Zhao,
- Changshan Liu,
- Jian Xu,
- Haitao Zhang,
- Lie Zhuo,
- Qiangquan Rong,
- Yu Xia,
- Qin Shen,
- Shao Li,
- Junhong Wang,
- Shengxian Wu
Affiliations
- Qinhua Fan
- Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
- Chongming Wu
- School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
- Yawei Du
- Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
- Boyang Wang
- Institute for TCM-X, MOE Key Laboratory of Bioinformatics, Bioinformatics Division, BNRist, Department of Automation, Tsinghua University, Beijing 100084, China
- Yanming Xie
- Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
- Zeling Zhang
- Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
- Wenquan Su
- Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
- Zizhuo Wang
- Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
- Changchang Xu
- Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
- Xueke Li
- Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
- Ying Ding
- The First Affiliated Hospital of Henan University of CM, Zhengzhou 450099, China
- Xinjiang An
- Xuzhou Children's Hospital, Xuzhou 221002, China
- Jing Chen
- Women and Children's Health Care Hospital of Linyi, Linyi 276016, China
- Yunying Xiao
- Taian Maternity and Child Health Hospital, Taian 271001, China
- Rong Yu
- Wuxi No.8 People's Hospital Group, Wuxi 214011, China
- Nan Li
- Shi Jia Zhuang Maternity & Child Healthcare Hospital, Shijiazhuang 050006, China
- Juan Wang
- The First People's Hospital of Lianyungang, Lianyungang 222002, China
- Yiqun Teng
- Jiaxing Second Hospital, Jiaxing 314001, China
- Hongfen Lv
- Jiangyan Hospital of Traditional Chinese Medicine, Taizhou 225599, China
- Nian Yang
- Linshu County People's Hospital, Linyi 276799, China
- Yuling Wen
- Qiqihar Hospital of Traditional Chinese Medicine, Qiqihar 161005, China
- Xiaoli Huang
- Liuzhou Maternal and Child Health Care Hospital, Liuzhou 545001, China
- Wei Pan
- Wuxi Hospital of Traditional Chinese Medicine, Wuxi 214071, China
- Yufeng Liu
- The Fourth Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110103, China
- Xueqin Xi
- Shandong Maternal and Child Health Hospital, Jinan 250014, China
- Qianye Zhao
- Lianyungang Maternal and Child Health Hospital, Lianyungang 222062, China
- Changshan Liu
- The Second Hospital of Tianjin Medical University, Tianjin 300211, China
- Jian Xu
- Qidong Maternal and Child Health Hospital, Qidong 226299, China
- Haitao Zhang
- Suzhou Integrated Traditional and Western Medicine Hospital, Suzhou 215101, China
- Lie Zhuo
- Nanjing Drum Tower Hospital Group Suqian Hospital, Nanjing 210008, China
- Qiangquan Rong
- Nanjing Gaochun People's Hospital, Nanjing 211302, China
- Yu Xia
- Nanjing Lishui People's Hospital, Nanjing 211299, China
- Qin Shen
- The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian 223812, China
- Shao Li
- Institute for TCM-X, MOE Key Laboratory of Bioinformatics, Bioinformatics Division, BNRist, Department of Automation, Tsinghua University, Beijing 100084, China; State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Lianyungang 222047, China; Corresponding authors.
- Junhong Wang
- Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China; Corresponding authors.
- Shengxian Wu
- Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China; Corresponding authors.
- Journal volume & issue
-
Vol. 14,
no. 12
pp. 5186 – 5200
Abstract
The comparison between traditional Chinese medicine Jinzhen oral liquid (JZOL) and Western medicine in treating children with acute bronchitis (AB) showed encouraging outcomes. This trial evaluated the efficacy and safety of the JZOL for improving cough and expectoration in children with AB. 480 children were randomly assigned to take JZOL or ambroxol hydrochloride and clenbuterol hydrochloride oral solution for 7 days. The primary outcome was time-to-cough resolution. The median time-to-cough resolution in both groups was 5.0 days and the antitussive onset median time was only 1 day. This randomized controlled trial showed that JZOL was not inferior to cough suppressant and phlegm resolving western medicine in treating cough and sputum and could comprehensively treat respiratory and systemic discomfort symptoms. Combined with clinical trials, the mechanism of JZOL against AB was uncovered by network target analysis, it was found that the pathways in TRP channels like IL-1β/IL1R/TRPV1/TRPA1, NGF/TrkA/TRPV1/TRPA1, and PGE2/EP/PKA/TRPV1/TRPA1 might play important roles. Animal experiments further confirmed that inflammation and the immune regulatory effect of JZOL in the treatment of AB were of vital importance and TRP channels were the key mechanism of action.
