DOT1L safeguards cartilage homeostasis and protects against osteoarthritis

Silvia Monteagudo; Frederique M. F. Cornelis; Carolina Aznar-Lopez; Ploi Yibmantasiri; Laura-An Guns; Peter Carmeliet; Frédéric Cailotto; Rik J. Lories

doi:10.1038/ncomms15889

Nature Communications (Jun 2017)

DOT1L safeguards cartilage homeostasis and protects against osteoarthritis

Silvia Monteagudo,
Frederique M. F. Cornelis,
Carolina Aznar-Lopez,
Ploi Yibmantasiri,
Laura-An Guns,
Peter Carmeliet,
Frédéric Cailotto,
Rik J. Lories

Affiliations

Silvia Monteagudo: Department of Development and Regeneration, Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven
Frederique M. F. Cornelis: Department of Development and Regeneration, Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven
Carolina Aznar-Lopez: Department of Development and Regeneration, Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven
Ploi Yibmantasiri: Department of Development and Regeneration, Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven
Laura-An Guns: Department of Development and Regeneration, Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven
Peter Carmeliet: Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism, KU Leuven
Frédéric Cailotto: Department of Development and Regeneration, Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven
Rik J. Lories: Department of Development and Regeneration, Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven

DOI: https://doi.org/10.1038/ncomms15889
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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DOT1L is one of the few genes linked to osteoarthritis by human GWAS. Here the authors show that DOT1L-dependent histone methylation protects homeostasis of articular chondrocytes by SIRT1-dependent inhibition of canonical WNT signalling, and that inhibition of DOT1L can drive osteoarthritic disease in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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