MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion

Robin Ferrari; Gaëlle Martin; Oya Tagit; Alan Guichard; Alessandra Cambi; Raphaël Voituriez; Stéphane Vassilopoulos; Philippe Chavrier

doi:10.1038/s41467-019-12930-y

Nature Communications (Oct 2019)

MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion

Robin Ferrari,
Gaëlle Martin,
Oya Tagit,
Alan Guichard,
Alessandra Cambi,
Raphaël Voituriez,
Stéphane Vassilopoulos,
Philippe Chavrier

Affiliations

Robin Ferrari: Sorbonne Université, Institut Curie, PSL Research University, CNRS, UMR 144
Gaëlle Martin: Institut Curie, PSL Research University, CNRS, UMR 144
Oya Tagit: Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen and Oncode Institute
Alan Guichard: Institut Curie, PSL Research University, CNRS, UMR 144
Alessandra Cambi: Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
Raphaël Voituriez: Sorbonne Université, CNRS, UMR 8237, Jean Perrin Laboratory
Stéphane Vassilopoulos: Sorbonne Université, INSERM UMRS 974, Institute of Myology
Philippe Chavrier: Institut Curie, PSL Research University, CNRS, UMR 144

DOI: https://doi.org/10.1038/s41467-019-12930-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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The mechanism of force production by invadopodia is unclear. Here, the authors show that cell surface MT1-MMP when in contact with collagen, induces Arp2/3 branched actin polymerisation on the concave side of invadopodia, which generates a pushing force along with collagen cleavage by MT1-MMP to invade.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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