PLoS ONE (Jan 2021)

Protocol of the Healthy Brain Study: An accessible resource for understanding the human brain and how it dynamically and individually operates in its bio-social context.

  • Healthy Brain Study consortium,
  • Esther Aarts,
  • Agnes Akkerman,
  • Mareike Altgassen,
  • Ronald Bartels,
  • Becky Beckers,
  • Kirsten Bevelander,
  • Erik Bijleveld,
  • Esmeralda Blaney Davidson,
  • Annemarie Boleij,
  • Janita Bralten,
  • Toon Cillessen,
  • Jurgen Claassen,
  • Roshan Cools,
  • Ineke Cornelissen,
  • Martin Dresler,
  • Thijs Eijsvogels,
  • Myrthe Faber,
  • Guillén Fernández,
  • Bernd Figner,
  • Matthias Fritsche,
  • Sascha Füllbrunn,
  • Surya Gayet,
  • Marleen M. H. J. van Gelder,
  • Marcel van Gerven,
  • Sabine Geurts,
  • Corina U. Greven,
  • Martine Groefsema,
  • Koen Haak,
  • Peter Hagoort,
  • Yvonne Hartman,
  • Beatrice van der Heijden,
  • Erno Hermans,
  • Vivian Heuvelmans,
  • Florian Hintz,
  • Janet den Hollander,
  • Anneloes M. Hulsman,
  • Sebastian Idesis,
  • Martin Jaeger,
  • Esther Janse,
  • Joost Janzing,
  • Roy P. C. Kessels,
  • Johan C. Karremans,
  • Willemien de Kleijn,
  • Marieke Klein,
  • Floris Klumpers,
  • Nils Kohn,
  • Hubert Korzilius,
  • Bas Krahmer,
  • Floris de Lange,
  • Judith van Leeuwen,
  • Huaiyu Liu,
  • Maartje Luijten,
  • Peggy Manders,
  • Katerina Manevska,
  • José P. Marques,
  • Jon Matthews,
  • James M. McQueen,
  • Pieter Medendorp,
  • René Melis,
  • Antje Meyer,
  • Joukje Oosterman,
  • Lucy Overbeek,
  • Marius Peelen,
  • Jean Popma,
  • Geert Postma,
  • Karin Roelofs,
  • Yvonne G. T. van Rossenberg,
  • Gabi Schaap,
  • Paul Scheepers,
  • Luc Selen,
  • Marianne Starren,
  • Dorine W. Swinkels,
  • Indira Tendolkar,
  • Dick Thijssen,
  • Hans Timmerman,
  • Rayyan Tutunji,
  • Anil Tuladhar,
  • Harm Veling,
  • Maaike Verhagen,
  • Jasper Verkroost,
  • Jacqueline Vink,
  • Vivian Vriezekolk,
  • Janna Vrijsen,
  • Jana Vyrastekova,
  • Selina van der Wal,
  • Roel Willems,
  • Arthur Willemsen

DOI
https://doi.org/10.1371/journal.pone.0260952
Journal volume & issue
Vol. 16, no. 12
p. e0260952

Abstract

Read online

The endeavor to understand the human brain has seen more progress in the last few decades than in the previous two millennia. Still, our understanding of how the human brain relates to behavior in the real world and how this link is modulated by biological, social, and environmental factors is limited. To address this, we designed the Healthy Brain Study (HBS), an interdisciplinary, longitudinal, cohort study based on multidimensional, dynamic assessments in both the laboratory and the real world. Here, we describe the rationale and design of the currently ongoing HBS. The HBS is examining a population-based sample of 1,000 healthy participants (age 30-39) who are thoroughly studied across an entire year. Data are collected through cognitive, affective, behavioral, and physiological testing, neuroimaging, bio-sampling, questionnaires, ecological momentary assessment, and real-world assessments using wearable devices. These data will become an accessible resource for the scientific community enabling the next step in understanding the human brain and how it dynamically and individually operates in its bio-social context. An access procedure to the collected data and bio-samples is in place and published on https://www.healthybrainstudy.nl/en/data-and-methods/access. Trail registration: https://www.trialregister.nl/trial/7955.