Nature Communications (Dec 2020)
AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion
- Anne Schuster,
- Eliane Klein,
- Virginie Neirinckx,
- Arnon Møldrup Knudsen,
- Carina Fabian,
- Ann-Christin Hau,
- Monika Dieterle,
- Anais Oudin,
- Petr V. Nazarov,
- Anna Golebiewska,
- Arnaud Muller,
- Daniel Perez-Hernandez,
- Sophie Rodius,
- Gunnar Dittmar,
- Rolf Bjerkvig,
- Christel Herold-Mende,
- Barbara Klink,
- Bjarne Winther Kristensen,
- Simone P. Niclou
Affiliations
- Anne Schuster
- NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Eliane Klein
- NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Virginie Neirinckx
- NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Arnon Møldrup Knudsen
- Department of Pathology, Odense University Hospital
- Carina Fabian
- NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Ann-Christin Hau
- NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Monika Dieterle
- NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Anais Oudin
- NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Petr V. Nazarov
- Quantitative Biology Unit, Luxembourg Institute of Health
- Anna Golebiewska
- NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Arnaud Muller
- Quantitative Biology Unit, Luxembourg Institute of Health
- Daniel Perez-Hernandez
- Quantitative Biology Unit, Luxembourg Institute of Health
- Sophie Rodius
- Quantitative Biology Unit, Luxembourg Institute of Health
- Gunnar Dittmar
- Quantitative Biology Unit, Luxembourg Institute of Health
- Rolf Bjerkvig
- NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- Christel Herold-Mende
- Division of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg
- Barbara Klink
- National Center of Genetics, Laboratoire National de Santé
- Bjarne Winther Kristensen
- Department of Pathology, Odense University Hospital
- Simone P. Niclou
- NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health
- DOI
- https://doi.org/10.1038/s41467-020-20029-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Glioblastomas (GBMs) are highly invasive brain tumours, but the underlying mechanisms of GBM invasion are unclear. Here, the authors perform an RNA interference screen and identify AN1-Type Zinc Finger protein 3 (ZFAND3) as a regulator of GBM invasion, and find that it acts through the transcriptional regulation of invasion-related genes.
