Nature Communications (Mar 2018)
Capture Hi-C identifies putative target genes at 33 breast cancer risk loci
- Joseph S. Baxter,
- Olivia C. Leavy,
- Nicola H. Dryden,
- Sarah Maguire,
- Nichola Johnson,
- Vita Fedele,
- Nikiana Simigdala,
- Lesley-Ann Martin,
- Simon Andrews,
- Steven W. Wingett,
- Ioannis Assiotis,
- Kerry Fenwick,
- Ritika Chauhan,
- Alistair G. Rust,
- Nick Orr,
- Frank Dudbridge,
- Syed Haider,
- Olivia Fletcher
Affiliations
- Joseph S. Baxter
- Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Olivia C. Leavy
- Department of Non-communicable Disease Epidemiology, The London School of Hygiene and Tropical Medicine
- Nicola H. Dryden
- Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Sarah Maguire
- Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Nichola Johnson
- Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Vita Fedele
- Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Nikiana Simigdala
- Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Lesley-Ann Martin
- Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Simon Andrews
- Bioinformatics Group, The Babraham Institute
- Steven W. Wingett
- Bioinformatics Group, The Babraham Institute
- Ioannis Assiotis
- Tumour Profiling Unit, The Institute of Cancer Research
- Kerry Fenwick
- Tumour Profiling Unit, The Institute of Cancer Research
- Ritika Chauhan
- Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Alistair G. Rust
- Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Nick Orr
- Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Frank Dudbridge
- Department of Non-communicable Disease Epidemiology, The London School of Hygiene and Tropical Medicine
- Syed Haider
- Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Olivia Fletcher
- Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- DOI
- https://doi.org/10.1038/s41467-018-03411-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Risk loci for breast cancer have been identified by genome-wide association studies. Here, the authors use Capture Hi-C to identify 110 putative target genes at 33 loci and assessed associations of gene expression, SNP genotype, and survival, providing evidence of mechanisms that may influence the prognosis and risk of breast cancer.
