Nature Communications (Mar 2018)
Ikaros family zinc finger 1 regulates dendritic cell development and function in humans
- Urszula Cytlak,
- Anastasia Resteu,
- Delfien Bogaert,
- Hye Sun Kuehn,
- Thomas Altmann,
- Andrew Gennery,
- Graham Jackson,
- Attila Kumanovics,
- Karl V. Voelkerding,
- Seraina Prader,
- Melissa Dullaers,
- Janine Reichenbach,
- Harry Hill,
- Filomeen Haerynck,
- Sergio D. Rosenzweig,
- Matthew Collin,
- Venetia Bigley
Affiliations
- Urszula Cytlak
- Institute of Cellular Medicine, Newcastle University
- Anastasia Resteu
- Institute of Cellular Medicine, Newcastle University
- Delfien Bogaert
- Primary Immunodeficiency Research Lab, Department of Pulmonary Medicine, Ghent University Hospital
- Hye Sun Kuehn
- Department of Laboratory Medicine NIH Clinical Center, National Institutes of Health
- Thomas Altmann
- Institute of Cellular Medicine, Newcastle University
- Andrew Gennery
- Institute of Cellular Medicine, Newcastle University
- Graham Jackson
- Newcastle upon Tyne Hospitals NHS Foundation Trust
- Attila Kumanovics
- Department of Pathology, University of Utah
- Karl V. Voelkerding
- Department of Pathology, University of Utah
- Seraina Prader
- Division of Immunology, University Children’s Hospital Zurich
- Melissa Dullaers
- Primary Immunodeficiency Research Lab, Department of Pulmonary Medicine, Ghent University Hospital
- Janine Reichenbach
- Division of Immunology, University Children’s Hospital Zurich
- Harry Hill
- Department of Pathology, University of Utah
- Filomeen Haerynck
- Primary Immunodeficiency Research Lab, Department of Pulmonary Medicine, Ghent University Hospital
- Sergio D. Rosenzweig
- Department of Laboratory Medicine NIH Clinical Center, National Institutes of Health
- Matthew Collin
- Institute of Cellular Medicine, Newcastle University
- Venetia Bigley
- Institute of Cellular Medicine, Newcastle University
- DOI
- https://doi.org/10.1038/s41467-018-02977-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
IKZF1 is a transcription factor known to regulate mammalian B-cell development. Here the authors show that IKZF1 is required for human pDC development and regulation of DC cytokine production in patients with IKZF1 haploinsufficiency, findings which are recapitulated in lenalidomide-induced IKZF1 deficiency.
