Pharmacoeconomical analysis of use of the low-molecular weight heparins for prevention of the venous tromboembolism in the conditions of multidisciplinary hospital

Abstract

for the first time in the Russian conditions the pharmacoeconomic analysis examined the application dalteparin in comparison with other low-molecular-weight heparins in patients with high risk of venous tromboembolism at the multifield hospital. On the basis of the systematic analysis of literature, two pharmacoeconomic models were constructed. The main model evaluated efficacy of thromboprophylactic strategy in surgical and therapeutic patients. The additional model included the patient with signigicant renal insufficiency with high risk of development of venous tromboembolism at hospitalization. This study estimated the cost of illness, probability of development different events in varied strategy of prevention, including side effects. In addition the sensitivity analysis was carried out. As a result, this study shown that the use of dalteparin in comparison with other low-molecularweight heparins in patients with high risk of venous tromboembolism in the conditions of the multifield hospital is economically rational medical technology.

Keywords

• pharmacoeconomics
• venous tromboembolism
• low-molecular-weight heparins