eLife (Sep 2024)
A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use
- Yihe Weng,
- Johann Kruschwitz,
- Laura M Rueda-Delgado,
- Kathy L Ruddy,
- Rory Boyle,
- Luisa Franzen,
- Emin Serin,
- Tochukwu Nweze,
- Jamie Hanson,
- Alannah Smyth,
- Tom Farnan,
- Tobias Banaschewski,
- Arun LW Bokde,
- Sylvane Desrivières,
- Herta Flor,
- Antoine Grigis,
- Hugh Garavan,
- Penny A Gowland,
- Andreas Heinz,
- Rüdiger Brühl,
- Jean-Luc Martinot,
- Marie-Laure Paillère Martinot,
- Eric Artiges,
- Jane McGrath,
- Frauke Nees,
- Dimitri Papadopoulos Orfanos,
- Tomas Paus,
- Luise Poustka,
- Nathalie Holz,
- Juliane Fröhner,
- Michael N Smolka,
- Nilakshi Vaidya,
- Gunter Schumann,
- Henrik Walter,
- Robert Whelan,
- IMAGEN Consortium
Affiliations
- Yihe Weng
- ORCiD
- School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland
- Johann Kruschwitz
- Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Collaborative Research Centre (SFB 940) 'Volition and Cognitive Control', Technische Universität Dresden, Dresden, Germany
- Laura M Rueda-Delgado
- ORCiD
- School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland
- Kathy L Ruddy
- ORCiD
- School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland; School of Psychology, Queens University Belfast, Belfast, United Kingdom
- Rory Boyle
- School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland
- Luisa Franzen
- School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland; Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands
- Emin Serin
- ORCiD
- Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Charité – Universitätsmedizin Berlin, Einstein Center for Neurosciences Berlin, Berlin, Germany; Bernstein Center for Computational Neuroscience, Berlin, Germany
- Tochukwu Nweze
- Department of Psychology, University of Utah, Salt Lake City, United States
- Jamie Hanson
- Department of Psychology, Learning Research & Development Center, University of Pittsburgh, Pittsburgh, United States
- Alannah Smyth
- School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland
- Tom Farnan
- ORCiD
- School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland
- Tobias Banaschewski
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- Arun LW Bokde
- Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
- Sylvane Desrivières
- Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology, & Neuroscience, SGDP Centre, King’s College London, London, United Kingdom
- Herta Flor
- Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Heidelberg University, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany
- Antoine Grigis
- NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France
- Hugh Garavan
- Departments of Psychiatry and Psychology, University of Vermont, Burlington, United States
- Penny A Gowland
- Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom
- Andreas Heinz
- Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
- Rüdiger Brühl
- ORCiD
- Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany
- Jean-Luc Martinot
- ORCiD
- Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 'Trajectoires développementales & psychiatrie', University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli, Gif-sur-Yvette, France
- Marie-Laure Paillère Martinot
- Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 'Trajectoires développementales & psychiatrie', University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli, Gif-sur-Yvette, France; AP-HP Sorbonne University, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France
- Eric Artiges
- Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 'Trajectoires développementales & psychiatrie', University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli, Gif-sur-Yvette, France; Psychiatry Department, EPS Barthélémy Durand, Etampes, France
- Jane McGrath
- Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
- Frauke Nees
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Heidelberg University, Mannheim, Germany; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany
- Dimitri Papadopoulos Orfanos
- ORCiD
- NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France
- Tomas Paus
- Departments of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hosptalier Universitaire Sainte-Justine, University of Montreal, Montreal, Canada; Departments of Psychiatry and Psychology, University of Toronto, Toronto, Canada
- Luise Poustka
- Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, Germany
- Nathalie Holz
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- Juliane Fröhner
- Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany
- Michael N Smolka
- ORCiD
- Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Berlin, Germany
- Nilakshi Vaidya
- Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China
- Gunter Schumann
- Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Berlin, Germany; Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China
- Henrik Walter
- Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
- Robert Whelan
- ORCiD
- School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland
- IMAGEN Consortium
- DOI
- https://doi.org/10.7554/eLife.97150
- Journal volume & issue
-
Vol. 13
Abstract
Substance use, including cigarettes and cannabis, is associated with poorer sustained attention in late adolescence and early adulthood. Previous studies were predominantly cross-sectional or under-powered and could not indicate if impairment in sustained attention was a predictor of substance use or a marker of the inclination to engage in such behavior. This study explored the relationship between sustained attention and substance use across a longitudinal span from ages 14 to 23 in over 1000 participants. Behaviors and brain connectivity associated with diminished sustained attention at age 14 predicted subsequent increases in cannabis and cigarette smoking, establishing sustained attention as a robust biomarker for vulnerability to substance use. Individual differences in network strength relevant to sustained attention were preserved across developmental stages and sustained attention networks generalized to participants in an external dataset. In summary, brain networks of sustained attention are robust, consistent, and able to predict aspects of later substance use.
Keywords
