Synthesis and biological evaluation of 1,2,3-triazole incorporated pyridin-4-yl)-1H-1,2,4-triazol-3-yl)pyrimidine derivatives as anticancer agents

Abstract

A new series of 1,2,3-triazole incorporated pyridin-4-yl)-1H-1,2,4-triazol-3-yl)pyrimidine (10a-j) has been synthesized and their structures were characterized by 1HNMR, 13CNMR and mass spectral data. The in vitro anticancer activity of these derivatives (10a-j) was evaluated against human cancer cell lines such as MCF-7 (human breast cancer), A549 (human lung cancer), Colo-205 (human colon cancer) and A2780 (human ovarian cancer) by employing the MTT method. The results were expressed as IC50 µM and most of the derivatives showed good to moderate activity as compared with etoposide which is used as a positive control. Among all the derivatives, six derivatives 10a, 10b, 10c, 10d, 10e and 10j showed more potent activity. Particularly, one compound 10a displayed the most promising activity.

Keywords

• Imatinib
• Pyrimidine
• Letrozole
• 1,2,4-Triazole and anticancer activity