Journal for ImmunoTherapy of Cancer (Dec 2016)
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: multiple myeloma, lymphoma, and acute leukemia
- Justin Kline,
- Ronald Levy,
- Joshua Brody,
- James N. Kochenderfer,
- Edmund K. Waller,
- Sundar Jagannath,
- Michael R. Bishop,
- David Siegel,
- David Avigan,
- Michael Boyiadzis,
- Jeffrey Miller,
- Rafat Abonour,
- Kenneth C. Anderson,
- Stephen M. Ansell,
- Lisa Barbarotta,
- Austin John Barrett,
- Koen Van Besien,
- P. Leif Bergsagel,
- Ivan Borrello,
- Jill Brufsky,
- Mitchell Cairo,
- Ajai Chari,
- Adam Cohen,
- Jorge Cortes,
- Stephen J. Forman,
- Jonathan W. Friedberg,
- Ephraim J. Fuchs,
- Steven D. Gore,
- Brad S. Kahl,
- Larry W. Kwak,
- Marcos de Lima,
- Mark R. Litzow,
- Anuj Mahindra,
- Nikhil C. Munshi,
- Robert Z. Orlowski,
- John M. Pagel,
- David L. Porter,
- Stephen J. Russell,
- Karl Schwartz,
- Margaret A. Shipp,
- Richard M. Stone,
- Martin S. Tallman,
- John M. Timmerman,
- Frits Van Rhee,
- Ann Welsh,
- Michael Werner,
- Peter H. Wiernik,
- Madhav V. Dhodapkar
Affiliations
- Justin Kline
- Aff22 grid.170205.10000000419367822The University of Chicago 5841 S. Maryland Ave 60637 Chicago IL USA
- Ronald Levy
- Aff25 grid.168010.e0000000419368956Division of Medical OncologyStanford University School of Medicine 269 Campus Drive 94305 Stanford CA USA
- Joshua Brody
- Aff12 grid.59734.3c0000000106702351Icahn School of Medicine at Mount Sinai One Gustave L Levy Place 10029 New York NY USA
- James N. Kochenderfer
- Aff23 grid.48336.3a0000000419368075National Institutes of Health, National Cancer Institute 8500 Roseweood Drive 20814 Bethesda MD USA
- Edmund K. Waller
- Aff40 grid.189967.80000000109416502Winship Cancer Institute, Emory University 1365B Clifton Road NE 30322 Atlanta GA USA
- Sundar Jagannath
- Icahn School of Medicine at Mount Sinai Tisch Cancer Institute, New York, New York, USA
- Michael R. Bishop
- Aff2 grid.170205.10000000419367822Hematopoietic Cellular Therapy ProgramUniversity of Chicago 5841 S. Maryland Avenue 60637 Chicago IL USA
- David Siegel
- Aff36 grid.239835.60000000404076328Hackensack University Medical Center 92 2nd St. 07601 Hackensack NJ USA
- David Avigan
- Aff6 grid.239395.70000000090118547Beth Israel Deaconess Medical Center 330 Brookline Avenue 02215 Boston MA USA
- Michael Boyiadzis
- Aff1 Division of Hematology-Oncology, Department of MedicineUniversity of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center 5150 Centre Avenue, Suite 564 15232 Pittsburg PA USA
- Jeffrey Miller
- 2University of Minnesota, Minneapolis, USA
- Rafat Abonour
- Aff3 grid.257413.60000000122873919Indiana University School of Medicine 980 W. Walnut St., Walther Hall-R3, C400 46202 Indianapolis IN USA
- Kenneth C. Anderson
- Aff4 grid.65499.370000000121069910Dana-Farber Cancer Institute 450 Brookline Avenue 02215 Boston MA USA
- Stephen M. Ansell
- Aff5 grid.66875.3a000000040459167XMayo Clinic 200 First Street SW 55905 Rochester MN USA
- Lisa Barbarotta
- Aff7 grid.490524.eSmilow Cancer Hospital at Yale New Haven 35 Park Street 06519 New Haven CT USA
- Austin John Barrett
- Aff8 grid.94365.3d0000000122975165National Institutes of Health Building 10-CRC Room 3-5330 20814 Bethesda MD USA
- Koen Van Besien
- Aff9 grid.5386.8000000041936877XWeill Cornell Medical College 407 E 71st St 10065 New York NY USA
- P. Leif Bergsagel
- Aff10 grid.417468.80000000088756339Mayo Clinic 13400 E. Shea Blvd. 85259 Scottsdale AZ USA
- Ivan Borrello
- Aff11 grid.21107.350000000121719311Johns Hopkins School of Medicine 1650 Orleans St 21231 Baltimore MD USA
- Jill Brufsky
- Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
- Mitchell Cairo
- Aff14 grid.260917.b000000010728151XNew York Medical College at Maria Fareri Children’s Hospital 100 Woods Road 10595 Valhalla New York USA
- Ajai Chari
- Icahn School of Medicine at Mount Sinai Tisch Cancer Institute, New York, New York, USA
- Adam Cohen
- Aff15 grid.25879.310000000419368972Abramson Cancer Center at the University of Pennsylvania 3400 Civic Center Blvd 19104 Philadelphia PA USA
- Jorge Cortes
- Aff16 grid.240145.60000000122914776MD Anderson Cancer Center 1515 Holcombe Blvd 77030 Houston TX USA
- Stephen J. Forman
- Aff17 grid.410425.60000000404218357City of Hope National Medical Center 1500 East Duarte Road 91010 Duarte CA USA
- Jonathan W. Friedberg
- Aff18 grid.16416.340000000419369174Wilmot Cancer InstituteUniversity of Rochester Box 704 601 Elmwood Avenue 14642 Rochester NY USA
- Ephraim J. Fuchs
- Aff19 grid.21107.350000000121719311Johns Hopkins University School of Medicine 401 N. Broadway 21231 Baltimore MD USA
- Steven D. Gore
- Aff20 grid.433818.5Yale Cancer Center 333 Cedar Street 06511 New Haven CT USA
- Brad S. Kahl
- Aff21 grid.4367.60000000123557002Washington University School of Medicine 660 S. Euclid Ave. 63110 St. Louis MO USA
- Larry W. Kwak
- Aff24 grid.410425.60000000404218357City of Hope National Medical Center 1500 E. Duarte Road, Beckman Bldg., Room 4117 91010 Duarte CA USA
- Marcos de Lima
- Aff26 grid.67105.350000000121643847Department of Medicine-Hematology and OncologyCase Western Reserve University 11100 Euclid Ave. 44106 Cleveland OH USA
- Mark R. Litzow
- Aff27 grid.66875.3a000000040459167XDepartment of HematologyMayo Clinic Cancer Center 200 First Street SW 55905 Rochester MN USA
- Anuj Mahindra
- Aff28 grid.266102.10000000122976811Helen Diller Family Comprehensive Cancer CenterUniversity of California San Francisco Box 0324 94143 San Francisco CA USA
- Nikhil C. Munshi
- Aff30 grid.65499.370000000121069910Dana-Farber Cancer Institute 450 Brookline Avenue, Dana B106 02215 Boston MA USA
- Robert Z. Orlowski
- Aff31 grid.240145.60000000122914776The University of Texas MD Anderson Cancer Center 1515 Holcombe Blvd., Unit 429 77030 Houston TX USA
- John M. Pagel
- Aff32 grid.281044.b0000000404635388Swedish Cancer Institute 1221 Madison Street, Suite 1020 98104 Seattle WA USA
- David L. Porter
- Aff33 grid.25879.310000000419368972University of Pennsylvania 3400 Civic Center Blvd, PCAM 12 South Pavilion 19104 Philadelphia PA USA
- Stephen J. Russell
- Aff5 grid.66875.3a000000040459167XMayo Clinic 200 First Street SW 55905 Rochester MN USA
- Karl Schwartz
- Aff34 Patients Against Lymphoma 3774 Buckwampum Road 18077 Riegelsville PA USA
- Margaret A. Shipp
- Aff35 grid.65499.370000000121069910Dana-Farber Cancer Institute 450 Brookline Ave, Mayer 513 02215 Boston MA USA
- Richard M. Stone
- Aff4 grid.65499.370000000121069910Dana-Farber Cancer Institute 450 Brookline Avenue 02215 Boston MA USA
- Martin S. Tallman
- Aff37 grid.51462.340000000121719952Memorial Sloan Kettering Cancer Center 1275 York Avenue 10065 New York NY USA
- John M. Timmerman
- Aff38 grid.19006.3e0000000096326718University of California, Los Angeles 10833 LeConte Ave. 90095 Los Angeles CA USA
- Frits Van Rhee
- Aff39 grid.241054.60000000446871637University of Arkansas for Medical Sciences, Myeloma Institute 4301 W Markham #816 72205 Little Rock AR USA
- Ann Welsh
- Aff41 grid.412689.00000000106507433University of Pittsburgh Medical Center 200 Lothrop St. 15213 Pittsburgh PA USA
- Michael Werner
- Aff42 Patient Advocate 33 East Bellevue Place 60611 Chicago IL USA
- Peter H. Wiernik
- Aff43 Cancer Research Foundation of New York 43 Longview Lane 10514 Chappaqua NY USA
- Madhav V. Dhodapkar
- Aff44 grid.47100.320000000419368710Department of Hematology & ImmunobiologyYale University Box 208021 333 Cedar Street 06510 New Haven CT USA
- DOI
- https://doi.org/10.1186/s40425-016-0188-z
- Journal volume & issue
-
Vol. 4,
no. 1
Abstract
Increasing knowledge concerning the biology of hematologic malignancies as well as the role of the immune system in the control of these diseases has led to the development and approval of immunotherapies that are resulting in impressive clinical responses. Therefore, the Society for Immunotherapy of Cancer (SITC) convened a hematologic malignancy Cancer Immunotherapy Guidelines panel consisting of physicians, nurses, patient advocates, and patients to develop consensus recommendations for the clinical application of immunotherapy for patients with multiple myeloma, lymphoma, and acute leukemia. These recommendations were developed following the previously established process based on the Institute of Medicine’s clinical practice guidelines. In doing so, a systematic literature search was performed for high-impact studies from 2004 to 2014 and was supplemented with further literature as identified by the panel. The consensus panel met in December of 2014 with the goal to generate consensus recommendations for the clinical use of immunotherapy in patients with hematologic malignancies. During this meeting, consensus panel voting along with discussion were used to rate and review the strength of the supporting evidence from the literature search. These consensus recommendations focus on issues related to patient selection, toxicity management, clinical endpoints, and the sequencing or combination of therapies. Overall, immunotherapy is rapidly emerging as an effective therapeutic strategy for the management of hematologic malignances. Evidence-based consensus recommendations for its clinical application are provided and will be updated as the field evolves.