Treatment of a massive naproxen overdose with therapeutic plasma exchange in a dog

Abstract

Abstract In comparison with other over‐the‐counter anti‐inflammatory drugs, naproxen has a longer half‐life in dogs and can lead to severe morbidity and mortality. This report describes the successful use of membrane‐based therapeutic plasma exchange after a massive ingestion of naproxen by a dog resulting in 86% reduction in plasma concentration.

Keywords

• acute kidney injury
• non‐steroidal anti‐inflammatory drugs
• therapeutic plasma exchange
• toxicity