Communications Biology (Mar 2022)
Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity
- Dapeng Li,
- Simon Brackenridge,
- Lucy C. Walters,
- Olivia Swanson,
- Karl Harlos,
- Daniel Rozbesky,
- Derek W. Cain,
- Kevin Wiehe,
- Richard M. Scearce,
- Maggie Barr,
- Zekun Mu,
- Robert Parks,
- Max Quastel,
- Robert J. Edwards,
- Yunfei Wang,
- Wes Rountree,
- Kevin O. Saunders,
- Guido Ferrari,
- Persephone Borrow,
- E. Yvonne Jones,
- S. Munir Alam,
- Mihai L. Azoitei,
- Geraldine M. Gillespie,
- Andrew J. McMichael,
- Barton F. Haynes
Affiliations
- Dapeng Li
- Duke Human Vaccine Institute, Duke University School of Medicine
- Simon Brackenridge
- Nuffield Department of Clinical Medicine, University of Oxford
- Lucy C. Walters
- Nuffield Department of Clinical Medicine, University of Oxford
- Olivia Swanson
- Duke Human Vaccine Institute, Duke University School of Medicine
- Karl Harlos
- Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford
- Daniel Rozbesky
- Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford
- Derek W. Cain
- Duke Human Vaccine Institute, Duke University School of Medicine
- Kevin Wiehe
- Duke Human Vaccine Institute, Duke University School of Medicine
- Richard M. Scearce
- Duke Human Vaccine Institute, Duke University School of Medicine
- Maggie Barr
- Duke Human Vaccine Institute, Duke University School of Medicine
- Zekun Mu
- Duke Human Vaccine Institute, Duke University School of Medicine
- Robert Parks
- Duke Human Vaccine Institute, Duke University School of Medicine
- Max Quastel
- Nuffield Department of Clinical Medicine, University of Oxford
- Robert J. Edwards
- Duke Human Vaccine Institute, Duke University School of Medicine
- Yunfei Wang
- Duke Human Vaccine Institute, Duke University School of Medicine
- Wes Rountree
- Duke Human Vaccine Institute, Duke University School of Medicine
- Kevin O. Saunders
- Duke Human Vaccine Institute, Duke University School of Medicine
- Guido Ferrari
- Department of Surgery, Duke University School of Medicine
- Persephone Borrow
- Nuffield Department of Clinical Medicine, University of Oxford
- E. Yvonne Jones
- Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford
- S. Munir Alam
- Duke Human Vaccine Institute, Duke University School of Medicine
- Mihai L. Azoitei
- Duke Human Vaccine Institute, Duke University School of Medicine
- Geraldine M. Gillespie
- Nuffield Department of Clinical Medicine, University of Oxford
- Andrew J. McMichael
- Nuffield Department of Clinical Medicine, University of Oxford
- Barton F. Haynes
- Duke Human Vaccine Institute, Duke University School of Medicine
- DOI
- https://doi.org/10.1038/s42003-022-03183-5
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 17
Abstract
The identification and structural analysis of HLA-E-VL9-targeting antibodies that block a natural killer (NK) cell receptor pathway and regulate NK function in vitro.
