Nature Communications (Sep 2020)

The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia

  • Daniel J. Ham,
  • Anastasiya Börsch,
  • Shuo Lin,
  • Marco Thürkauf,
  • Martin Weihrauch,
  • Judith R. Reinhard,
  • Julien Delezie,
  • Fabienne Battilana,
  • Xueyong Wang,
  • Marco S. Kaiser,
  • Maitea Guridi,
  • Michael Sinnreich,
  • Mark M. Rich,
  • Nitish Mittal,
  • Lionel A. Tintignac,
  • Christoph Handschin,
  • Mihaela Zavolan,
  • Markus A. Rüegg

DOI
https://doi.org/10.1038/s41467-020-18140-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 21

Abstract

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mTORC1 expression is increased during ageing of muscle, and on the other hand, its activation promotes muscle hypertrophy. Here, the authors assess whether mTORC1 has positive or negative effects on ageing, and show that its long-term inhibition preserves muscle mass and function and neuromuscular junction integrity, whereas muscle-specific activation is associated with sarcopenia.