ROLE OF THYROID DYSFUNCTION IN INFERTILE WOMEN WITH MENSTRUAL DISTURBANCES

Abstract

Background: Normal thyroid function is necessary to maintain reproductive physiology. An abnormality in its function may be the cause of infertility manifesting as abnormal menstrual cycle. The objective of this study was to find the role of thyroid dysfunction in primary and secondary infertile women with menstrual disturbances. Material & Methods: A total of 168 subjects comprising of 106 primary and 62 secondary infertile women were evaluated. Their detailed clinical and menstrual histories were obtained and their blood samples were taken for thyroid profile. Results: Out of 168 infertile patients 134(79.76%) had euthyroid, 31(18.45%) hyperthyroid and only 3(1.78%) patients had hypothyroid profile. Irregular menstrual cycles were found in 10 out of 31 (32.25%) hyperthyroid, 2 out of 3 (66.66%) hypothyroid and 21 out of 134 (15.67%) euthyroid infertile women. A significant p-value was obtained on comparison of thyroid profile with irregularities in menstrual cycle. Conclusion: It was found that an abnormal thyroid profile may be the cause of infertility in women presenting with menstrual disturbances.

Keywords

• female infertility
• thyroid hormones
• menstruation disturbances
• menstrual cycle
• hpothyroidism
• hyperthyroidism.