Nature Communications (Jul 2020)
H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
- Kolja Schleich,
- Julia Kase,
- Jan R. Dörr,
- Saskia Trescher,
- Animesh Bhattacharya,
- Yong Yu,
- Elizabeth M. Wailes,
- Dorothy N. Y. Fan,
- Philipp Lohneis,
- Maja Milanovic,
- Andrea Lau,
- Dido Lenze,
- Michael Hummel,
- Bjoern Chapuy,
- Ulf Leser,
- Maurice Reimann,
- Soyoung Lee,
- Clemens A. Schmitt
Affiliations
- Kolja Schleich
- Charité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum
- Julia Kase
- Charité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum
- Jan R. Dörr
- Charité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum
- Saskia Trescher
- Institute for Computer Science, Humboldt-Universität zu Berlin
- Animesh Bhattacharya
- Charité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum
- Yong Yu
- Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association
- Elizabeth M. Wailes
- Charité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum
- Dorothy N. Y. Fan
- Charité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum
- Philipp Lohneis
- University Hospital Cologne
- Maja Milanovic
- Charité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum
- Andrea Lau
- Charité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum
- Dido Lenze
- Charité – University Medical Center
- Michael Hummel
- Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner Site Berlin
- Bjoern Chapuy
- University Medical Center Göttingen, Department of Hematology and Medical Oncology
- Ulf Leser
- Institute for Computer Science, Humboldt-Universität zu Berlin
- Maurice Reimann
- Charité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum
- Soyoung Lee
- Charité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum
- Clemens A. Schmitt
- Charité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum
- DOI
- https://doi.org/10.1038/s41467-020-17467-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Therapy-induced senescence reflects a biological effector principle that is underrecognized in lesion-focused cancer precision medicine. Here the authors utilize mouse lymphoma genetics to functionally dissect senescence and cross-species apply a novel senescence-based prognosticator to lymphoma patients.
