Role of USP13 in physiology and diseases

Qian Wang; Qian Wang; Qian Wang; Zhenzhen Sun; Zhenzhen Sun; Zhenzhen Sun; Weiwei Xia; Weiwei Xia; Weiwei Xia; Le Sun; Le Sun; Le Sun; Yang Du; Yang Du; Yang Du; Yue Zhang; Yue Zhang; Yue Zhang; Zhanjun Jia; Zhanjun Jia; Zhanjun Jia

doi:10.3389/fmolb.2022.977122

Frontiers in Molecular Biosciences (Sep 2022)

Role of USP13 in physiology and diseases

Qian Wang,
Qian Wang,
Qian Wang,
Zhenzhen Sun,
Zhenzhen Sun,
Zhenzhen Sun,
Weiwei Xia,
Weiwei Xia,
Weiwei Xia,
Le Sun,
Le Sun,
Le Sun,
Yang Du,
Yang Du,
Yang Du,
Yue Zhang,
Yue Zhang,
Yue Zhang,
Zhanjun Jia,
Zhanjun Jia,
Zhanjun Jia

Affiliations

Qian Wang: Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China
Qian Wang: Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China
Qian Wang: Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, China
Zhenzhen Sun: Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China
Zhenzhen Sun: Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China
Zhenzhen Sun: Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, China
Weiwei Xia: Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China
Weiwei Xia: Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China
Weiwei Xia: Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, China
Le Sun: Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China
Le Sun: Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China
Le Sun: Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, China
Yang Du: Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China
Yang Du: Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China
Yang Du: Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, China
Yue Zhang: Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China
Yue Zhang: Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China
Yue Zhang: Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, China
Zhanjun Jia: Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China
Zhanjun Jia: Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China
Zhanjun Jia: Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, China

DOI: https://doi.org/10.3389/fmolb.2022.977122
Journal volume & issue: Vol. 9

Abstract

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Ubiquitin specific protease (USP)-13 is a deubiquitinase that removes ubiquitin from substrates to prevent protein degradation by the proteasome. Currently, the roles of USP13 in physiology and pathology have been reported. In physiology, USP13 is highly associated with cell cycle regulation, DNA damage repair, myoblast differentiation, quality control of the endoplasmic reticulum, and autophagy. In pathology, it has been reported that USP13 is important in the pathogenesis of infection, inflammation, idiopathic pulmonary fibrosis (IPF), neurodegenerative diseases, and cancers. This mini-review summarizes the most recent advances in USP13 studies involving its pathophysiological roles in different conditions and provides new insights into the prevention and treatment of relevant diseases, as well as further research on USP13.

Published in Frontiers in Molecular Biosciences

ISSN: 2296-889X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/molecular-biosciences

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