Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics

Caillan Crowe-McAuliffe; Victoriia Murina; Kathryn Jane Turnbull; Susanne Huch; Marje Kasari; Hiraku Takada; Lilit Nersisyan; Arnfinn Sundsfjord; Kristin Hegstad; Gemma C. Atkinson; Vicent Pelechano; Daniel N. Wilson; Vasili Hauryliuk

doi:10.1038/s41467-022-29274-9

Nature Communications (Apr 2022)

Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics

Caillan Crowe-McAuliffe,
Victoriia Murina,
Kathryn Jane Turnbull,
Susanne Huch,
Marje Kasari,
Hiraku Takada,
Lilit Nersisyan,
Arnfinn Sundsfjord,
Kristin Hegstad,
Gemma C. Atkinson,
Vicent Pelechano,
Daniel N. Wilson,
Vasili Hauryliuk

Affiliations

Caillan Crowe-McAuliffe: Institute for Biochemistry and Molecular Biology, University of Hamburg
Victoriia Murina: Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University
Kathryn Jane Turnbull: Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University
Susanne Huch: SciLifeLab, Department of Microbiology, Tumor and Cell Biology. Karolinska Institutet
Marje Kasari: Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University
Hiraku Takada: Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University
Lilit Nersisyan: SciLifeLab, Department of Microbiology, Tumor and Cell Biology. Karolinska Institutet
Arnfinn Sundsfjord: Department of Microbiology and Infection Control, Norwegian National Advisory Unit on Detection of Antimicrobial Resistance, University Hospital of North Norway
Kristin Hegstad: Department of Microbiology and Infection Control, Norwegian National Advisory Unit on Detection of Antimicrobial Resistance, University Hospital of North Norway
Gemma C. Atkinson: Umeå Centre for Microbial Research (UCMR), Umeå University
Vicent Pelechano: SciLifeLab, Department of Microbiology, Tumor and Cell Biology. Karolinska Institutet
Daniel N. Wilson: Institute for Biochemistry and Molecular Biology, University of Hamburg
Vasili Hauryliuk: Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University

DOI: https://doi.org/10.1038/s41467-022-29274-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

Read online

PoxtA confers resistance to ribosome-targeting oxazolidinone (linezolid) and chloramphenicol antibiotics. Here, Crowe-McAuliffe et al. provide structural insights into how binding of PoxtA to the ribosome indirectly promotes drug dissociation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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