Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

Amika Singla; Alina Fedoseienko; Sai S. P. Giridharan; Brittany L. Overlee; Adam Lopez; Da Jia; Jie Song; Kayci Huff-Hardy; Lois Weisman; Ezra Burstein; Daniel D. Billadeau

doi:10.1038/s41467-019-12221-6

Nature Communications (Sep 2019)

Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

Amika Singla,
Alina Fedoseienko,
Sai S. P. Giridharan,
Brittany L. Overlee,
Adam Lopez,
Da Jia,
Jie Song,
Kayci Huff-Hardy,
Lois Weisman,
Ezra Burstein,
Daniel D. Billadeau

Affiliations

Amika Singla: Department of Internal Medicine, and Department of Molecular Biology, University of Texas Southwestern Medical Center
Alina Fedoseienko: Division of Oncology Research and Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic
Sai S. P. Giridharan: Life Sciences Institute, University of Michigan
Brittany L. Overlee: Division of Oncology Research and Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic
Adam Lopez: Department of Internal Medicine, and Department of Molecular Biology, University of Texas Southwestern Medical Center
Da Jia: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, Division of Neurology, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University
Jie Song: Department of Internal Medicine, and Department of Molecular Biology, University of Texas Southwestern Medical Center
Kayci Huff-Hardy: Department of Internal Medicine, and Department of Molecular Biology, University of Texas Southwestern Medical Center
Lois Weisman: Life Sciences Institute, University of Michigan
Ezra Burstein: Department of Internal Medicine, and Department of Molecular Biology, University of Texas Southwestern Medical Center
Daniel D. Billadeau: Division of Oncology Research and Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic

DOI: https://doi.org/10.1038/s41467-019-12221-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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Recycling of proteins that have entered the endosome is essential to homeostasis. The COMMD/CCDC22/CCDC93 (CCC) complex is regulator of recycling but the molecular mechanisms are unclear. Here, the authors report that the CCC complex regulates endosomal recycling by maintaining PI3P levels on endosomal membranes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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