Facile and general electrochemical deuteration of unactivated alkyl halides

Pengfei Li; Chengcheng Guo; Siyi Wang; Dengke Ma; Tian Feng; Yanwei Wang; Youai Qiu

doi:10.1038/s41467-022-31435-9

Nature Communications (Jun 2022)

Facile and general electrochemical deuteration of unactivated alkyl halides

Pengfei Li,
Chengcheng Guo,
Siyi Wang,
Dengke Ma,
Tian Feng,
Yanwei Wang,
Youai Qiu

Affiliations

Pengfei Li: State Key Laboratory and Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University
Chengcheng Guo: State Key Laboratory and Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University
Siyi Wang: State Key Laboratory and Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University
Dengke Ma: State Key Laboratory and Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University
Tian Feng: State Key Laboratory and Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University
Yanwei Wang: State Key Laboratory and Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University
Youai Qiu: State Key Laboratory and Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University

DOI: https://doi.org/10.1038/s41467-022-31435-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 8

Abstract

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Deuterium-labelled compounds are useful for mechanistic studies and pharmaceutical science, but syntheses are not trivial. Here, the authors report deuteration of unactivated alkyl (pseudo)halides driven by electrochemical force, using deuterium oxide as the source of the isotope.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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