Nature Communications (Feb 2019)

Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response

  • Xabier Agirre,
  • Cem Meydan,
  • Yanwen Jiang,
  • Leire Garate,
  • Ashley S. Doane,
  • Zhuoning Li,
  • Akanksha Verma,
  • Bruno Paiva,
  • José I. Martín-Subero,
  • Olivier Elemento,
  • Christopher E. Mason,
  • Felipe Prosper,
  • Ari Melnick

DOI
https://doi.org/10.1038/s41467-019-08679-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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Long non-coding RNAs (lncRNA) constitute a large fraction of human transcriptome, and are reported, individually, for context-specific regulatory functions. Here the authors expand our understanding by providing a systemic, unbiased annotation of lncRNA to establish an atlas of lncRNA landscape during the induction of human humoral immune responses.