Journal of Clinical and Translational Science (Jan 2023)
Development, implementation, and dissemination of operational innovations across the trial innovation network
- Marisha E. Palm,
- Terri L. Edwards,
- Cortney Wieber,
- Marie T. Kay,
- Eve Marion,
- Leslie Boone,
- Angeline Nanni,
- Michelle Jones,
- Eilene Pham,
- Meghan Hildreth,
- Karen Lane,
- Nichol McBee,
- Daniel K. Benjamin,
- Gordon R. Bernard,
- J. Michael Dean,
- Jamie P. Dwyer,
- Daniel E. Ford,
- Daniel F. Hanley,
- Paul A. Harris,
- Consuelo H. Wilkins,
- Harry P. Selker
Affiliations
- Marisha E. Palm
- ORCiD
- Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, USA
- Terri L. Edwards
- Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA
- Cortney Wieber
- Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, USA
- Marie T. Kay
- University of Utah Health, Salt Lake City, UT, USA
- Eve Marion
- ORCiD
- Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
- Leslie Boone
- Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA
- Angeline Nanni
- Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Michelle Jones
- Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA
- Eilene Pham
- Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
- Meghan Hildreth
- Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Karen Lane
- ORCiD
- Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA Institute for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Nichol McBee
- Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Daniel K. Benjamin
- Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA Duke University School of Medicine, Durham, NC, USA
- Gordon R. Bernard
- Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
- J. Michael Dean
- University of Utah Health, Salt Lake City, UT, USA
- Jamie P. Dwyer
- University of Utah Health, Salt Lake City, UT, USA Utah Clinical and Translational Sciences Institute, Salt Lake City, UT, USA
- Daniel E. Ford
- ORCiD
- Institute for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Daniel F. Hanley
- ORCiD
- Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA Institute for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Paul A. Harris
- ORCiD
- Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA Department of Biomedical Informatics, Biostatistics, and Biomedical Engineering, Vanderbilt University Medical Center, Nashville, TN, USA
- Consuelo H. Wilkins
- Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA Department of Internal Medicine, Meharry Medical College, Nashville, Tennessee, USA
- Harry P. Selker
- ORCiD
- Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, USA
- DOI
- https://doi.org/10.1017/cts.2023.658
- Journal volume & issue
-
Vol. 7
Abstract
Improving the quality and conduct of multi-center clinical trials is essential to the generation of generalizable knowledge about the safety and efficacy of healthcare treatments. Despite significant effort and expense, many clinical trials are unsuccessful. The National Center for Advancing Translational Science launched the Trial Innovation Network to address critical roadblocks in multi-center trials by leveraging existing infrastructure and developing operational innovations. We provide an overview of the roadblocks that led to opportunities for operational innovation, our work to develop, define, and map innovations across the network, and how we implemented and disseminated mature innovations.
Keywords
