Isolation and Structural Elucidation of Chondrosterins F–H from the Marine Fungus Chondrostereum sp.

Abstract

The marine fungus Chondrostereum sp. was collected from a soft coral of the species Sarcophyton tortuosum from the South China Sea. Three new compounds, chondrosterins F–H (1, 4 and 5), together with three known compounds, incarnal (2), arthrosporone (3), and (2E)-decene-4,6,8-triyn-1-ol (6), were isolated. Their structures were elucidated primarily based on NMR and MS data. Incarnal (2) exhibited potent cytotoxic activity against various cancer cell lines.

Keywords

• Chondrostereum sp.
• sesquiterpenoids
• chondrosterins
• marine fungus
• cytotoxic activities