Engineered niches support the development of human dendritic cells in humanized mice

Giorgio Anselmi; Kristine Vaivode; Charles-Antoine Dutertre; Pierre Bourdely; Yoann Missolo-Koussou; Evan Newell; Oliver Hickman; Kristie Wood; Alka Saxena; Julie Helft; Florent Ginhoux; Pierre Guermonprez

doi:10.1038/s41467-020-15937-y

Nature Communications (Apr 2020)

Engineered niches support the development of human dendritic cells in humanized mice

Giorgio Anselmi,
Kristine Vaivode,
Charles-Antoine Dutertre,
Pierre Bourdely,
Yoann Missolo-Koussou,
Evan Newell,
Oliver Hickman,
Kristie Wood,
Alka Saxena,
Julie Helft,
Florent Ginhoux,
Pierre Guermonprez

Affiliations

Giorgio Anselmi: Centre for Inflammation Biology and Cancer Immunology, The Peter Gorer Department of Immmunobiology, King’s College London
Kristine Vaivode: Centre for Inflammation Biology and Cancer Immunology, The Peter Gorer Department of Immmunobiology, King’s College London
Charles-Antoine Dutertre: Singapore Immunology Network (SIgN), A*STAR
Pierre Bourdely: Centre for Inflammation Biology and Cancer Immunology, The Peter Gorer Department of Immmunobiology, King’s College London
Yoann Missolo-Koussou: Paris-Sciences-Lettres University, Institut Curie Research Center, INSERM U932 & SiRIC, Translational Immunotherapy Team
Evan Newell: Singapore Immunology Network (SIgN), A*STAR
Oliver Hickman: Centre for Inflammation Biology and Cancer Immunology, The Peter Gorer Department of Immmunobiology, King’s College London
Kristie Wood: National Institute of Health Research Biomedical Research Centre at Guy’s and St Thomas’ Hospital and King’s College London
Alka Saxena: National Institute of Health Research Biomedical Research Centre at Guy’s and St Thomas’ Hospital and King’s College London
Julie Helft: Paris-Sciences-Lettres University, Institut Curie Research Center, INSERM U932 & SiRIC, Translational Immunotherapy Team
Florent Ginhoux: Singapore Immunology Network (SIgN), A*STAR
Pierre Guermonprez: Centre for Inflammation Biology and Cancer Immunology, The Peter Gorer Department of Immmunobiology, King’s College London

DOI: https://doi.org/10.1038/s41467-020-15937-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 18

Abstract

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Classical human dendritic cells (cDCs) are rare sentinel cells specialized in regulating adaptive immunity. Here, the authors show that expression of membrane bound FLT3L, along with stem cell factor (SCF) and CXCL12 in stromal cells induces specification of pre/AS-DCs, type 1 and type2 cDC from haematopoietic stem cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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