Nature Communications (Jan 2023)
The H2A.Z and NuRD associated protein HMG20A controls early head and heart developmental transcription programs
- Andreas Herchenröther,
- Stefanie Gossen,
- Tobias Friedrich,
- Alexander Reim,
- Nadine Daus,
- Felix Diegmüller,
- Jörg Leers,
- Hakimeh Moghaddas Sani,
- Sarah Gerstner,
- Leah Schwarz,
- Inga Stellmacher,
- Laura Victoria Szymkowiak,
- Andrea Nist,
- Thorsten Stiewe,
- Tilman Borggrefe,
- Matthias Mann,
- Joel P. Mackay,
- Marek Bartkuhn,
- Annette Borchers,
- Jie Lan,
- Sandra B. Hake
Affiliations
- Andreas Herchenröther
- Institute for Genetics, Justus-Liebig University Giessen
- Stefanie Gossen
- Department of Biology, Molecular Embryology, Philipps University Marburg
- Tobias Friedrich
- Institute for Biochemistry, Justus-Liebig University Giessen
- Alexander Reim
- Department of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry
- Nadine Daus
- Institute for Genetics, Justus-Liebig University Giessen
- Felix Diegmüller
- Institute for Genetics, Justus-Liebig University Giessen
- Jörg Leers
- Institute for Genetics, Justus-Liebig University Giessen
- Hakimeh Moghaddas Sani
- School of Life and Environmental Sciences, University of Sydney
- Sarah Gerstner
- Department of Biology, Molecular Embryology, Philipps University Marburg
- Leah Schwarz
- Department of Biology, Molecular Embryology, Philipps University Marburg
- Inga Stellmacher
- Institute for Genetics, Justus-Liebig University Giessen
- Laura Victoria Szymkowiak
- Institute for Genetics, Justus-Liebig University Giessen
- Andrea Nist
- Genomics Core Facility, Institute of Molecular Oncology, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research (DZL), Philipps-University Marburg
- Thorsten Stiewe
- Genomics Core Facility, Institute of Molecular Oncology, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research (DZL), Philipps-University Marburg
- Tilman Borggrefe
- Institute for Biochemistry, Justus-Liebig University Giessen
- Matthias Mann
- Department of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry
- Joel P. Mackay
- School of Life and Environmental Sciences, University of Sydney
- Marek Bartkuhn
- Biomedical Informatics and Systems Medicine, Science Unit for Basic and Clinical Medicine, Institute for lung health, Justus-Liebig University Giessen
- Annette Borchers
- Department of Biology, Molecular Embryology, Philipps University Marburg
- Jie Lan
- Institute for Genetics, Justus-Liebig University Giessen
- Sandra B. Hake
- Institute for Genetics, Justus-Liebig University Giessen
- DOI
- https://doi.org/10.1038/s41467-023-36114-x
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 20
Abstract
How the histone variant H2A.Z controls cell fate remains unclear. Here, the authors reveal that the H2A.Z interacting partner HMG20A plays a key role in regulating transcription during early head and heart development.
