Association between Cardiovascular Diseases and Peri-Implantitis: A Systematic Review and Meta-Analysis

Abstract

Background: A potential relationship between oral inflammation and cardiovascular disease has been proposed; however, the impact of cardiovascular disease on implant restoration remains unclear. This systematic review aims to assess the relationship between peri-implantitis and cardiovascular disease based on review of data obtained through observational studies. Materials and Methods: An extensive systematic literature search was performed using the PubMed/MEDLINE, Scopus, Web of Science and Cochrane Library databases. Studies published in English language up to June 2022 were conducted in accordance with PRISMA guidelines. These efforts identified 230 unique publications and, after selection, five studies were included in this meta-analysis. The Newcastle-Ottawa Scale table was used for literature quality assessment. A fixed-effect model was selected and RevMan software version 5.3 was used to identify the origin of the outcomes of the meta-analysis. Finally, results were reported through the PRISMA statement. Results: This meta-analysis found that in implant restoration the incidence of peri-implantitis in patients with cardiovascular disease was higher than those without cardiovascular disease (Risk ratio (RR) = 1.12; 95% CI: 1.02–1.23; z = 2.34; p < 0.05). Conclusions: Based on current evidence, we conclude that the presence of cardiovascular disease increases the incidence of peri-implantitis. Registration: PROSPERO database (CRD42022353693).

Keywords

• dental implants
• cardiovascular diseases
• epidemiology
• inflammation
• biomarkers
• peri-implantitis