Nature Communications (Mar 2022)
Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals
- Prokopis C. Prokopiou,
- Nina Engels-Domínguez,
- Kathryn V. Papp,
- Matthew R. Scott,
- Aaron P. Schultz,
- Christoph Schneider,
- Michelle E. Farrell,
- Rachel F. Buckley,
- Yakeel T. Quiroz,
- Georges El Fakhri,
- Dorene M. Rentz,
- Reisa A. Sperling,
- Keith A. Johnson,
- Heidi I. L. Jacobs
Affiliations
- Prokopis C. Prokopiou
- Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
- Nina Engels-Domínguez
- Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
- Kathryn V. Papp
- Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School
- Matthew R. Scott
- Department of Neurology, Massachusetts General Hospital, Harvard Medical School
- Aaron P. Schultz
- Department of Neurology, Massachusetts General Hospital, Harvard Medical School
- Christoph Schneider
- Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
- Michelle E. Farrell
- Department of Neurology, Massachusetts General Hospital, Harvard Medical School
- Rachel F. Buckley
- Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School
- Yakeel T. Quiroz
- Department of Neurology, Massachusetts General Hospital, Harvard Medical School
- Georges El Fakhri
- Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
- Dorene M. Rentz
- Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School
- Reisa A. Sperling
- Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School
- Keith A. Johnson
- Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
- Heidi I. L. Jacobs
- Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-022-28986-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Older individuals exhibiting diminished function of the locus coeruleus while learning new information show faster cognitive decline that is typical for Alzheimer’s disease.
