Nature Communications (Jun 2016)

Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation

  • Jun Li,
  • Cancan Chen,
  • Xiancai Ma,
  • Guannan Geng,
  • Bingfeng Liu,
  • Yijun Zhang,
  • Shaoyang Zhang,
  • Fudi Zhong,
  • Chao Liu,
  • Yue Yin,
  • Weiping Cai,
  • Hui Zhang

DOI
https://doi.org/10.1038/ncomms11730
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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Long noncoding RNAs have a wide range of physiological functions, though their role in viral infection and latency is poorly understood. Here the authors show a lncRNA NRON can induce degradation of HIV-1 protein Tat, potentially contributing to latent infection.