Successful immunosuppressive drug‐free immune tolerance induction in hemophilia B with inhibitor and anaphylaxis to factor IX: A case report

Abstract

Key Clinical Message Recommendations advise factor IX desensitization before immune tolerance induction in severe hemophilia B, supported by immunosuppression. A child with inhibitor and anaphylaxis to factor IX showed successful immunosuppression‐free immune tolerance induction using very low and slowly increasing doses of a factor IX extended‐half‐life product. Immune tolerance to factor IX based on this protocol merits further study.

Keywords

• anaphylaxis reaction
• desensitization protocol
• factor IX‐extended half‐life product
• immune tolerance induction
• inhibitors
• severe hemophilia B