Efficacy of linezolid in the treatment of tuberculous meningitis: a meta-analysis

Abstract

Introduction Tuberculous meningitis (TBM) is a severe extra-pulmonary tuberculosis with high fatality. This meta-analysis aimed to assess the impact of linezolid on TBM treatment outcomes. Methods We searched multiple databases for studies published up to May 18, 2024 comparing the effects of linezolid on TBM. Meta-analysis was conducted using Review Manager 5.4. Results Our findings indicated that linezolid may reduce treatment failure risk (RR = 0.42 (0.20, 0.89), p = 0.02) and improve temperature recovery (RR = 1.56 (1.21, 2.02), p < 0.001) in TBM patients. Conclusions The analysis suggests a positive association between linezolid treatment and therapeutic improvements, with no significant adverse reactions reported.

Keywords

• tuberculous meningitis
• linezolid
• efficacy
• treatment outcome
• temperature recovery
• meta-analysi