Molecular docking, synthesis and antimicrobial evaluation of metal complexes with Schiff base

Abstract

The appearance of resistant bacteria was found to reduce the efficiency of antimicrobial therapies with the current antibiotics, thereby increasing the need for more efficient drugs for the treatment of infections. A microbial infection affects tremendously to the human health and antimicrobials are one of the mainly successful forms of chemotherapy which saves the human population from the risk of infectious diseases. In this regard, the present study involves synthesis of transition metal complexes have often shown the immense antimicrobial activity. In this article, metal complexes were synthesized using different metals such as of Zn(II), Hg(II), Pt(II) and Pd(II), using Schiff’s base derived from amino and carbonyl ligand. All the synthesized compounds were characterized using IR, NMR, and mass spectral data and also by UV–visible spectra, molar electric conductance, magnetic susceptibility and thermal studies. Moreover, the antimicrobial activities of metal complexes were demonstrated using both gram negative and gram positive bacteria. The synthetic series of title compounds 6a-d, the compounds 6c and 6d with platinum and palladium metal were found to be active. The complex 6c has shown excellent antimicrobial activity and the result was also confirmed by molecular docking.

Keywords

• Antibiotics, Synthesis
• Schiff bases
• Metal complexes
• Antimicrobial activity
• Molecular Docking